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The transgenic construct contains an untagged human profilin 1 (PFN1) cDNA sequence (420 bp) under the direction of mouse prion protein promoter. Expression is detected in brain, spinal cord, and to a lesser extent in skeletal muscle. The transgene is not expressed in the liver. Founder line 850 was identified with total PFN1 protein levels in spinal cord at ~4-fold greater levels compared to endogenous mouse PFN1 protein levels in non-transgenic mice. (J:241428)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
