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The heart restricted murine alpha-myosin heavy chain promoter drives the expression of human cardiac actin with a glycine substitution for glutamic acid at amino acid 361 (E361G). This is a dominant negative mutation. Two lines were established: 361.20 and 361.13. Mice express this mutation at around 50% of total actin in the heart. (J:242344)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
