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A bacterial artificial chromosome (BAC) library was used to obtain a 110 kb BAC containing the entire human glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene. A loxP-flanked STOP signal, followed by a human catalase (CAT) gene, was inserted into this BAC to replace exons 3-7 of GAPDH. The initiating methionine of CAT was deleted, and the first 25 amino acids of the ornithine transcarbamylase (Otc) leader sequence were added to the amino terminus to target this protein product to mitochondria. (J:183593)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
