A neomycin resistance cassette has replaced exons 3-6, which encode the first and second CUB domains of the protein. Immunofluorescence analysis of mammary glands of homozygous mutant females at puberty (5 weeks), late pregnancy (day 18), and early lactation (postpartum day 2) detected no expression of the targeted gene at any developmental stage. (J:242064)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129
Targeted
Insertion, Intragenic deletion
Recessive
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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