A neomycin resistance cassette has replaced exons 3-6, which encode the first and second CUB domains of the protein. Immunofluorescence analysis of mammary glands of homozygous mutant females at puberty (5 weeks), late pregnancy (day 18), and early lactation (postpartum day 2) detected no expression of the targeted gene at any developmental stage. (J:242064)
Basic Information
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count