The targeting vector contains a loxP site upstream of exon 1 and a FRT-site flanked PGK-neo-bGHpA cassette followed by a loxP downstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exons 1 and 2 floxed. (J:241641)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count