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A dominant-negative mutant neuron-restrictive silencer factor cDNA is under the control of the cardiac-specific alpha-MHC promoter. Two lines, 471 and 474, were generated. mRNA is expressed at a level 27-fold higher than endogenous mRNA in this line. Western blot confirmed that expression is restricted to the heart, though weak expression is seen in the lung. (J:86837)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
