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An frt site flanked hygromycin resistance gene cassette was inserted in intron 4. Exon 5 was flanked by loxP sites. Exon 5 codes for part of the active catalytic domain including the Thr175 phosphorylation site within the activation loop. The hygro cassette was removed through subsequent FLP-mediated recombination, leaving a conditional-ready allele with a floxed exon 5. (J:242343)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
