LoxP sites were inserted flanking exons 3 and 4, which encode 20 of the 24 conserved, functionally required cysteine residues. Mice carrying this allele were crossed with CMV-Cre mice to delete the loxP-flanked region. (J:242196)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count