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CRISPR-Cas9 methodology is used to introduce a knock-in DNA methylation reporter (Snrpn*/GFP) adjacent to the 3' end of the Dlk1-Dio3 locus on mouse chromosome 12 (the IG-DMR, intergenic differentially methylated region).The Snrpn*/GFP cassette contains a GFP fused to the minimal promoter region of the mouse Snrpn gene; it includes conserved elements and the endogenous imprinted differentially methylated region. Maternal inheritance of the reporter allele is required to express the GFP reporter. (J:239124)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
