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The CAG promoter drives the expression of floxed lacZ followed by three polyadenylation (pA) signals. Following this is the Nos1ap open reading frame (ORF, NM_001109985) including start and stop codons; this is then followed by an IRES-puromycin-pA cassette. In the presence of cre recombinase, the floxed lacZ-polyA cassette is deleted, leaving Nos1ap under the control of the strong constitutive enhancer-promoter element. This leads to Nos1ap overexpression in the tissues in which cre recombinase is expressed. Lines 112, 314 and 333 were generated. (J:232078)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
