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The transgene contains an EGFP inserted upstream and in frame of the mouse Tfrc gene with a G to A point mutation that results in the amino acid substitution of histidine for arginine at position 649 (R649H). Three lines were generated with line 1 designated as the representative line. This substitution is predicted to produce a dominant negative protein. (J:241563)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
