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A cDNA encoding rat TNNC1 (troponin C, cardiac/slow skeletal) carrying an L48Q (CTG->CAG) mutation and a FLAG epitope tag was placed under the regulatory control of the mouse Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter and the tetracycline responsive element (tetO). Translation is terminated by a human growth hormone polyadenylation signal. When active, the transgene elicits ~40% incorporation of the mutant cardiac troponin C into the cardiac muscle sarcomere. (J:234490)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
