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Mice bearing this transgene conditionally express FLAG-tagged rat Tnnc1 (troponin C, cardiac/slow skeletal) cDNA carrying an I61Q (ATC->CAG) mutation under the control of the mouse cardiac-specific Myh6 (myosin, heavy polypeptide 6, cardiac muscle, alpha) promoter and the tetracycline responsive element (tetO). The transgene elicits ~45% incorporation of the mutant cardiac troponin C into the cardiac muscle sarcomere. (J:234490)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
