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CRISPR/Cas9 mutagenesis was used to create a mutation of a C/G base pair inserted into the coding region right after start codon, disrupting the open reading frame. The guide RNA targeted the coding region sequence 5'-GACATCCCGCCGC-3'. Western blot analysis confirmed that the expression of the encoded protein was ablated. (J:235704)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
