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All coding exons of the gene and part of the non-coding exon 1 were replaced by a Neomycin resistance (NeoR) cassette flanked by frt sequences. Chimeras were bred with mice expressing FLIPase constitutively to remove the Neo cassette and generate the recombined allele. Western blotting validated the absence of PAXX protein in murine embryonic fibroblasts derived from homozygous mutant mice. (J:238544)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
