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A CAG promoter and a loxP site flanked puromycin resistance gene and ECFP reporter gene double cassette were inserted upstream of exon 1 replacing the native promoter. Subsequent cre-mediated recombination removed the selection/reporter cassette, bringing the gene under the constitutively active control of the CAG promoter. The expression from this allele is around tenfold higher than from the wild-type allele. The half-life of the transcripts is the same as wild-type. (J:239949)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
