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A single loxP site is inserted 3' to exon 5. An Frt-PGK-Neo-Frt-loxP cassette was inserted to the 5'-end of exon 3. The neo cassette was removed by crossing to mice carrying the Frt recombinase driven by the beta-actin promoter, leaving single loxP sites flanking exons 3-5. Cre-mediated recombination resulted in excision of exons 3-5. Western blot analysis confirmed the absence of protein in homozygous mutant tissues. (J:237513)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
