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A targeting vector with a cDNA sequence encoding the CreER fusion gene, followed by a frt-flanked neomycin selection cassette replaced the open reading frame of the Foxc2 gene via homologouse recombination in C57BL/6-derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts, and chimeric males were bred with C57BL/6 for germline transmission. At some point, they were bred with ROSA26::FLPe mice (on a C57BL/6J genetic background) for germline deletion of the neo selection cassette. (J:228882)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
