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The transgene encodes the alpha and beta chains of a mouse T cell receptor (TCR) specific for the H2-Db-restricted epitope of histocompatibilty Y (HYA, a.k.a. H-Y), WMHHNMDLI, derived from the ubiquitously transcribed tetratricopeptide repeat gene, Y chromosome (Uty). The recombined T cell receptor alpha (Tcra-V15-J16) and beta (Tcrb-V8.3-J1.1) variable region sequences of the MataHari CD8+ T cell clone were inserted into TCRalpha and TCRbeta shuttle vectors, which were then co-injected into fertilized mouse oocytes. The MataHari clone was derived from a B6.A-H2ba H2-T18a/Boy (a.k.a. C57BL/6-Tlaa) female mouse that had been immunized with spleen cells from a male mouse of the same strain. (J:183981)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
