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The rat insulin II promoter drives the expression in pancreatic beta cells a form of Akt1 that has been rendered constitutively active by the addition of an N-terminal myristoylation sequence. Western blot confirmed expression of the transgene in pancreatic lysates. Two lines were generated, F3 and F7. (J:72216)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
