The targeting vector is designed to insert a single loxP site 450bp upstream of the start codon and a loxP and FRT-flanked neomycin resistance (neo) cassette downstream of exon 1. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:101977)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count