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Exon 4 was targeted with (a) point mutation(s) resulting in an S231A codon change. A loxP site and an FRT site flanked neomycin resistance gene cassette were inserted into intron 3 and a further loxP site into intron 4. The neo cassette was removed through flp-mediated recombination. This leaves modified exon 4 floxed. The codon change prevents phosphorylation of amino-acid 231 in the translated peptide. (J:234284)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
