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Nonchemically modified deoxyribonucleotides were used to introduce the (5-CAAGGCGATCCAGAGAATCAGGACCGGGAAAAGGTAAAGTC-3) mutation into a mouse ES cell line. This alteration is an insertion of 4 nucleotides (AGGA) to generate the Brca15382stop mutation, which resulted in premature protein truncation at aa 1713 and closely resembled the human BRCA15382insC mutation. (J:237116)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
