This allele from project Dusp18-8276J-M2282 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences AGAGACCGTGAACAATGGAA, GGTCTTTTCACACAGAGGAA, GAACTCCTCAGGCCGCAGAG and GCAAATCCCTAAAACAGGTA, which resulted in a 4631 bp deletion beginning at Chromosome 11 positive strand position 3,896,766 bp CATTGTTCACGGTCTCTCTG, and ending after AAGGGAACTCCTCAGGCCGC at 3,901,396 bp (GRCm38/mm10). This mutation deletes exon 2, which is the only translated exon, along with 277 bp of flanking intronic sequence, including the splice acceptor and donor, so it is predicted to result in a complete null. (J:188991)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NJ
Endonuclease-mediated
Intragenic deletion
Not Specified
1
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Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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