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A neomycin selection cassette replaced a genomic fragment containing exons 3 and 4. Various tissues of homozygous mice failed to express detectable transcripts, as detected by semiquantitative real-time PCR. Total sphingosine-1-phosphate phosphatase (SPPase) enzymatic activity was decreased by ~30% in the membrane fraction from homozygous mutant lung tissue. (J:235035)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
