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A 7021-bp full-length human Notch3 cDNA carrying the codon 90 CGT to TGT mutation was ligated to a 2191-bp fragment of the TAGLN gene promoter, including 2126 bp upstream of the initiation transcription site and the complete noncoding first exon. A 584 bp fragment of the bovine beta-globin intron was inserted between the SM22alpha regulatory sequence and the Notch3 sequence. A polyadenylation signal was derived from the SV40 poly(A) DNA and was inserted at the 3 end of the construct. Three lines were generated; lines Ma (1, mauve) and Ve (2, verte) were used for further analysis. (J:129831)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
