A targeting vector was designed to insert a loxP site into intron 11, a loxP-FRT-flanked neomycin cassette into intron 13 and a G844D point mutation into exon 15. Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination removed exons 12 and 13. (J:210296)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129 x C57BL/6
Targeted
Insertion, Intragenic deletion
--
1
8
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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