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A loxP site was inserted located 5 of exon 13, and a neomycin resistance (neor) gene flanked with two frt sites, and a loxP site were inserted 3 of exon 13. Mice were crossed with FLP-expressing and Cre-expressing transgenic mice to remove the frt flanked neoR cassette and loxP flanked exon 13, resulting in a frame-shift mutation in exon 14. (J:238366)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
