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Exon 5 was flanked by loxP sites and an FRT site flanked reporter-selection double cassette was inserted into intron 4. The double cassette consists of a beta galactosidase (lacZ) gene cassette separated from a neomycin resistance gene cassette by a loxP site. The lacZ-neo double cassette was removed through flp-mediated recombination. Exon 5 was deleted by cre-mediated recombination, creating a knock-out allele. RT-PCR confirmed lack of wild-type transcripts. (J:237769)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
