Exons 6 and 7 were flanked by loxP sites. In addition, an EGFP gene and Neo selection cassette separated by a loxP site and flanked by FRT sites was inserted upstream of the floxed exons 6-7. Flp-mediated recombination removed the FRT-flanked EGFP and Neo selection cassette, leaving an FRT site and floxed exons 6-7. (J:237188)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count