A targeting construct incorporating exons 1-8 is used to place a loxP-flanked neomycin cassette in intron 1, and remove U32a, U33, U34, and U35a small nucleolar RNAs (snoRNAs) from introns 2, 4, 5, and 6, respectively. Cre-mediated recombination removed the floxed neo cassette. Rpl13a mRNA and protein levels are indistinguishable from wild-type controls. (J:237822)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S5/SvEvBrd
Targeted
Intragenic deletion
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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