Log In|Sign Up
EN
A targeting vector containing a human HBEGF diphtheria-toxin receptor (DTR) cDNA linked in frame to the dsRed Express2 fluorescent protein by a 2A peptide, a FRT-flanked PGKneo cassette, a bovine growth hormone polyadenylation signal and two loxP sites, are used to disrupt the translation initiation codon in exon 2. DsRed fluorescence is detected in small intestine Paneth cells and colonic deep crypt secretory cells, and mimics the endogenous Reg4 gene expression pattern. No red fluorescence is detected in pancreas, stomach, or liver. (J:235576)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
