This allele from project Slc26a10-8158J-F2393 was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences GGAGTGGCAGATATATCGTG, ATTGTGTTGGTCCTTTTCGG, GGTCTTCTAAGAGAGCGGAT and GCAGCAGCCAGGAACCGATG, which resulted in a 444 bp deletion beginning at Chromosome 10 positive strand position 127,178,593 bp, CGATATATCTGCCACTCCGG, and ending after CTGGTGCAGCAGCCAGGAAC at 127,179,036 bp (GRCm38/mm10). This mutation deletes exon 3 and 286 bp of flanking intronic sequence including the splice acceptor and donor, and is predicted to cause a change of amino acid sequence after residue 159 and early truncation 144 amino acids later. (J:188991)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count