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The CRISPR/Cas9 system was used to generate a 25-bp deletion in exon 1. Exon 1 is present in the longer Hnrnpa3a protein isoform but absent in the shorter Hnrnpa3b isoform. Immunoblot analysis revealed a marked reduction in the level of Hnrnpa3a, but not Hnrnpa3b, in the brain of homozygous mutant mice at E14.5. Immunostaining revealed that protein levels were barely detectable in the ventricular zone (VZ) and subventricular zone (SVZ) regions at E13.5. (J:237332, J:288307)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
