Cre-mediated excision of the parental Snap29tm1a(EUCOMM)Wtsi allele resulted in the removal of the critical exon 2 leaving behind the inserted lacZ/neo cassette. Removal of exon 2 introduces a frameshift with early termination at the eighth codon in Exon 3. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:236759)