An FRT-site flanked PGKneo selection cassette containing was inserted downstream of exon 3 of the targeted gene, and another loxP site was inserted upstream of exon 3. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 3 floxed. Cre-mediated recombination removed exon 3. (J:236328)
Basic Information
(129S6/SvEvTac x C57BL/6J)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count