The targeting vector contains an FRT-loxP-neomycin-FRT-loxP cassette introduced upstream of exon 24 and a loxP site downstream of exon 24. Exon 24 encodes the catalytic JmjC domain. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 24 floxed. (J:227020)
Basic Information
(C57BL/6J x 129S4/SvJae)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count