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The human alpha-synuclein bearing the oligomer-prone E57K mutation is under the control of neuronal mouse Thy1 promoter. Three lines were generated. Lines 9 and 16 are high expressers, and line 54 is a lower expressing line. Size exclusion chromatography confirmed the formation of oligomeric alpha-synuclein. (J:236596)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
