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The transgene is designed with ~5 kbp mouse nestin promoter/enhancer sequences, a ~1.1 kbp modified herpes simplex virus thymidine kinase fragment (delta-HSV-TK), a ~1.3 kbp IRES-eGFP cassette, an SV40 polyadenylation sequence and a ~0.8 kbp mouse nestin intron 2 sequence. Thymidine kinase xpression is coincident with early hippocampal progenitors. The investigator reports that eGFP expression is observable by direct fluorescence and can be enhanced it with antibody staining. (J:142499)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
