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The transgene contains the entire solute carrier family 6 (neurotransmitter transporter GABA) member 11 locus (Slc6a11 [GAT3 or Gabt4]), as well as ~48 kbp 5' (centromeric) flanking region and ~36 kbp 3' (telomeric) flanking region from BAC RP23-470B21. Using homologous recombination/BAC recombineering, a CreER cDNA sequence followed by an SV40 polyadenylation signal was inserted into exon 1 of the BAC Slc6a11 gene immediately preceding the translation initiation codon. No other loci on the BAC were altered. Unstated number of founder lines with germline transmission are generated. A founder line #1 was established and characterized. (J:249928)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
