CRISPR/Cas technology targeted exon 2 to generate a knock-out allele lacking 23 nucleotides. Western blot analysis confirmed an 80% reduction in protein levels in the testes. (J:233657)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count