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An F3 site flanked puromycin resistance cassette was inserted upstream of exon 7. Exon 9 was replaced with a modified one in which nucleotide substitutions (GAA to GCT) that result in the amino acid substitution of glutamic acid with alanine at position 861 (p.E861A). This mutation is predicted to produce a catalyticly inactivated protein. Flp-mediated recombination removed the selection cassette. (J:226177)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
