Log In|Sign Up
EN
The 695 amino acid isoform of human amyloid precursor protein with the Swedish (K670N and M671L) and London (V717I) mutations is under the control of the tetracycline-response element and the Prnp promoter. Western blot analysis indicate transgene expression at a level four times that of the endogenous mouse protein in the membrane-enriched fraction of the brain. (J:235351)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
