Flp recombinase-mediated deletion of a frt-flanked Pgk-neo cassette from Bmp2tm1Rog has left a loxP site 76 bp past the translation termination codon and a single frt site followed by a second loxP site 446 base pairs downstream of the stop codon. The loxP sites flank an ultraconserved sequence (UCS) in the 3' untranslated region (3'-UTR) of the mouse gene that mediates post-transcriptional repression of protein synthesis. (J:242911)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
Insertion
--
1
7
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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