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A 124 base pair (bp) loxP site has replaced a PvuII restriction enzyme recognition site 76 bp past the translation termination codon, and a Pgk-neomycin phosphotransferase cassette flanked by frt sites and followed by a second loxP site has replaced an AccI recognition site 446 bp downstream of the stop codon. The loxP sites flank both the frt-flanked selection cassette and an ultraconserved sequence (UCS) in the 3' untranslated region (3'-UTR) of the mouse gene that mediates post-transcriptional repression of protein synthesis. (J:242911)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
