A targeting vector containing a T2A viral 2A peptide, iCre recombinase sequence, T2A viral 2A peptide, multicistronic element (derived from insect Thosea asigna virus 2A), and FRT site flanked NEO cassette was inserted upstream of the Trpm2 gene stop codon. The resulting chimeric animals were crossed to FLPeR recombinase (Gt(ROSA)26Sor) expressing females to excise the FRT site flanked NEO cassette. (J:235274)
Basic Information
(C57BL/6 x 129P2/OlaHsd)F1
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count