A targeting vector containing a T2A viral 2A peptide, iCre recombinase sequence, T2A viral 2A peptide, multicistronic element (derived from insect Thosea asigna virus 2A), and FRT site flanked NEO cassette was inserted upstream of the Trpm2 gene stop codon. The resulting chimeric animals were crossed to FLPeR recombinase (Gt(ROSA)26Sor) expressing females to excise the FRT site flanked NEO cassette. (J:235274)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
(C57BL/6 x 129P2/OlaHsd)F1
Targeted
Insertion
--
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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