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A loxP site was inserted upstream of the cluster of microRNAs. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of teh cluster. Flp-mediated recombination removed the selection cassette and left the cluster floxed. As confirmed by QRT-PCR, cre-mediated removal of the the microRNA cluster does not alter transcript expression of the host gene Larp6. (J:233994)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
