Sgcd^tm1Ojml

Exon 6 was replaced with a modified exon in which a T to G point mutation results in the amino acid substitution of alanine for serine at position 151 (S151A). This amino acid substitution is reported in patients with autosomal dominant dilated cardiomyopathy. A neomycin resistance cassette was inserted downstream of the modified exon. (J:234761)