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A targeting construct was designed to replace exon 1, including the translation start, of the bone morphogenetic protein 7 (Bmp7) gene with a creER fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain). The Cre/ER sequence is followed by a hGHpA cassette (human Growth Hormone polyadenylation signal) and a frt-flanked puromycin resistance (puro) cassette. The chimeric mice were bred to mice expressing FLP Recombinase to remove puro cassette. (J:101977)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
