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Sequence from the human ortholog (consisting of the 1 kb 3' UTR from haplotype B which has the C allele of SNP rs1054204, the consensus polyA site and a G-T rich region), preceded by a loxP site flanked neomycin resistance gene cassette, was flanked by 8-10 kb long mouse homology arms. This construct was targeted to the mouse gene and used to replace the endogenous 3' UTR in exon 10 with the human 3' UTR. Subsequent cre-mediated recombination excised the neo cassette. (J:233364)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
